Petasites hybridus extracts in vitro inhibit COX-2 and PGE2 release by direct interaction with the enzyme and by preventing p42/44 MAP kinase activation in rat primary microglial cells. [electronic resource]
Producer: 20050329Description: 12-9 p. digitalISSN:- 0032-0943
- Animals
- Cyclooxygenase 1
- Cyclooxygenase 2
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase Inhibitors -- administration & dosage
- Dinoprostone -- metabolism
- Dose-Response Relationship, Drug
- Enzyme Activation -- drug effects
- Inhibitory Concentration 50
- Membrane Proteins
- Microglia -- cytology
- Mitogen-Activated Protein Kinases -- drug effects
- Petasites
- Phytotherapy
- Plant Extracts -- administration & dosage
- Prostaglandin-Endoperoxide Synthases -- drug effects
- Rats
- Rats, Wistar
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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