Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain. [electronic resource]
Producer: 20090821Description: 2599-603 p. digitalISSN:- 1464-3405
- Analgesics -- chemical synthesis
- Animals
- Central Nervous System -- drug effects
- Chemistry, Pharmaceutical -- methods
- Drug Design
- Humans
- Hydrogen-Ion Concentration
- Inflammation -- drug therapy
- Inhibitory Concentration 50
- Models, Chemical
- Nicotinic Acids -- chemical synthesis
- Pyridines -- chemical synthesis
- Rats
- Receptors, Prostaglandin E -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Journal Article
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