Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. [electronic resource]
Producer: 20100224Description: 158-69 p. digitalISSN:- 1476-5403
- Amino Acid Substitution
- Animals
- Apoptosis
- Brain -- metabolism
- Caspase 6 -- metabolism
- Cells, Cultured
- Dimerization
- Down-Regulation
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Mice
- Mutagenesis, Site-Directed
- Mutation
- Oncogene Proteins -- genetics
- Parkinson Disease -- genetics
- Protein Deglycase DJ-1
- Tumor Suppressor Protein p53 -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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