Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers. [electronic resource]
Producer: 20020404Description: 323-30 p. digitalISSN:- 0008-543X
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Calcitonin -- blood
- Carcinoma, Medullary -- diagnosis
- Catecholamines -- urine
- Child
- Child, Preschool
- DNA Mutational Analysis
- DNA Primers -- chemistry
- DNA, Neoplasm -- blood
- Drosophila Proteins
- Female
- Germ-Line Mutation -- genetics
- Humans
- Hyperplasia -- pathology
- Infant
- Male
- Middle Aged
- Multiple Endocrine Neoplasia Type 2a -- genetics
- Multiple Endocrine Neoplasia Type 2b -- genetics
- Omeprazole -- metabolism
- Pentagastrin -- metabolism
- Polymerase Chain Reaction
- Prognosis
- Proto-Oncogene Mas
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins c-ret
- Receptor Protein-Tyrosine Kinases -- genetics
- Thyroid Gland -- pathology
- Thyroid Neoplasms -- diagnosis
- Thyroidectomy
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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