Anti-tumor necrosis factor VNAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock. [electronic resource]
Producer: 20130703Description: 17 p. digitalISSN:- 1471-2172
- Animals
- Biomarkers -- blood
- Disease Models, Animal
- Humans
- Inflammation -- blood
- Interleukin-10 -- metabolism
- Interleukin-6 -- metabolism
- Lipopolysaccharides
- Liver -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Nitrates -- metabolism
- Nitric Oxide Synthase Type II -- metabolism
- Protein Structure, Tertiary
- RNA, Messenger -- genetics
- Shock, Septic -- blood
- Single-Domain Antibodies -- therapeutic use
- Survival Analysis
- Treatment Outcome
- Tumor Necrosis Factor-alpha -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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