Dual inhibition of Bcr-Abl and Hsp90 by C086 potently inhibits the proliferation of imatinib-resistant CML cells. [electronic resource]
Producer: 20151209Description: 833-43 p. digitalISSN:- 1557-3265
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Curcumin -- analogs & derivatives
- Drug Resistance, Neoplasm
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- HSP90 Heat-Shock Proteins -- antagonists & inhibitors
- Humans
- Imatinib Mesylate
- Immunoblotting
- Immunoprecipitation
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- pathology
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Neoplastic Stem Cells -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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