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Discovery and SAR of substituted 3-oxoisoindoline-4-carboxamides as potent inhibitors of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. [electronic resource] by
- Gandhi, Viraj B
- Luo, Yan
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Park, Chang
- Giranda, Vincent L
- Penning, Thomas D
- Zhu, Gui-Dong
Producer: 20100920
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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4.
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Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt. [electronic resource] by
- Zhu, Gui-Dong
- Gong, Jianchun
- Gandhi, Viraj B
- Woods, Keith
- Luo, Yan
- Liu, Xuesong
- Guan, Ran
- Klinghofer, Vered
- Johnson, Eric F
- Stoll, Vincent S
- Mamo, Mulugeta
- Li, Qun
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20070424
In:
Bioorganic & medicinal chemistry vol. 15
Availability: No items available.
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5.
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Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituent. [electronic resource] by
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Thomas, Sheela
- Luo, Yan
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Frost, David
- Donawho, Cherrie
- Jarvis, Ken
- Bouska, Jennifer
- Marsh, Kennan C
- Rosenberg, Saul H
- Giranda, Vincent L
- Penning, Thomas D
Producer: 20081117
In:
Bioorganic & medicinal chemistry letters vol. 18
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6.
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Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer. [electronic resource] by
- Zhu, Gui-Dong
- Gong, Jianchun
- Gandhi, Viraj B
- Liu, Xuesong
- Shi, Yan
- Johnson, Eric F
- Donawho, Cherrie K
- Ellis, Paul A
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Park, Chang
- Luo, Yan
- Shoemaker, Alexander
- Giranda, Vincent L
- Penning, Thomas D
Producer: 20121207
In:
Bioorganic & medicinal chemistry vol. 20
Availability: No items available.
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Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Donawho, Cherrie K
- Frost, David J
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Giranda, Vincent L
Producer: 20090223
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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8.
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Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancers. [electronic resource] by
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Luo, Yan
- Liu, Xuesong
- Shi, Yan
- Guan, Ran
- Magnone, Shayna R
- Klinghofer, Vered
- Johnson, Eric F
- Bouska, Jennifer
- Shoemaker, Alexander
- Oleksijew, Anatol
- Jarvis, Ken
- Park, Chang
- Jong, Ron De
- Oltersdorf, Tilman
- Li, Qun
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20060802
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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9.
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Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity. [electronic resource] by
- Zhu, Gui-Dong
- Gong, Jianchun
- Claiborne, Akiyo
- Woods, Keith W
- Gandhi, Viraj B
- Thomas, Sheela
- Luo, Yan
- Liu, Xuesong
- Shi, Yan
- Guan, Ran
- Magnone, Shayna R
- Klinghofer, Vered
- Johnson, Eric F
- Bouska, Jennifer
- Shoemaker, Alexander
- Oleksijew, Anatol
- Stoll, Vincent S
- De Jong, Ron
- Oltersdorf, Tilman
- Li, Qun
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20060816
In:
Bioorganic & medicinal chemistry letters vol. 16
Availability: No items available.
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10.
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Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gong, Jianchun
- Thomas, Sheela
- Gandhi, Viraj B
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Park, Chang H
- Fry, Elizabeth H
- Donawho, Cherrie K
- Frost, David J
- Buchanan, Fritz G
- Bukofzer, Gail T
- Rodriguez, Luis E
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Osterling, Donald J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Giranda, Vincent L
Producer: 20100514
In:
Journal of medicinal chemistry vol. 53
Availability: No items available.
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11.
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Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer. [electronic resource] by
- Penning, Thomas D
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Thomas, Sheela
- Lubisch, Wilfried
- Grandel, Roland
- Wernet, Wolfgang
- Park, Chang H
- Fry, Elizabeth H
- Liu, Xuesong
- Shi, Yan
- Klinghofer, Vered
- Johnson, Eric F
- Donawho, Cherrie K
- Frost, David J
- Bontcheva-Diaz, Velitchka
- Bouska, Jennifer J
- Olson, Amanda M
- Marsh, Kennan C
- Luo, Yan
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20080911
In:
Bioorganic & medicinal chemistry vol. 16
Availability: No items available.
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12.
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Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. [electronic resource] by
- Zhu, Gui-Dong
- Gandhi, Viraj B
- Gong, Jianchun
- Thomas, Sheela
- Woods, Keith W
- Song, Xiaohong
- Li, Tongmei
- Diebold, R Bruce
- Luo, Yan
- Liu, Xuesong
- Guan, Ran
- Klinghofer, Vered
- Johnson, Eric F
- Bouska, Jennifer
- Olson, Amanda
- Marsh, Kennan C
- Stoll, Vincent S
- Mamo, Mulugeta
- Polakowski, James
- Campbell, Thomas J
- Martin, Ruth L
- Gintant, Gary A
- Penning, Thomas D
- Li, Qun
- Rosenberg, Saul H
- Giranda, Vincent L
Producer: 20080902
In:
Journal of medicinal chemistry vol. 50
Availability: No items available.
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