The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease. [electronic resource]
Producer: 20201109Description: 10062 p. digitalISSN:- 2045-2322
- Adrenergic beta-Antagonists -- pharmacology
- Apoptosis
- Cell Nucleus -- metabolism
- Central Nervous System Neoplasms -- complications
- Hemangioblastoma -- complications
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Molecular Targeted Therapy
- Mutation -- genetics
- Neovascularization, Pathologic
- Propanolamines -- pharmacology
- Signal Transduction
- Tumor Cells, Cultured
- Von Hippel-Lindau Tumor Suppressor Protein -- genetics
- von Hippel-Lindau Disease -- complications
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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