A cell culture-derived whole-virus H9N2 vaccine induces high titer antibodies against hemagglutinin and neuraminidase and protects mice from severe lung pathology and weight loss after challenge with a highly virulent H9N2 isolate. [electronic resource]
Producer: 20121023Description: 4625-31 p. digitalISSN:- 1873-2518
- Animals
- Antibodies, Neutralizing -- blood
- Antibodies, Viral -- blood
- Dose-Response Relationship, Immunologic
- Female
- Guinea Pigs
- Hemagglutination Inhibition Tests
- Hemagglutinin Glycoproteins, Influenza Virus -- immunology
- Influenza A Virus, H9N2 Subtype -- immunology
- Influenza Vaccines -- immunology
- Lung -- pathology
- Mice
- Mice, Inbred BALB C
- Neuraminidase -- immunology
- Neutralization Tests
- Orthomyxoviridae Infections -- immunology
- Weight Loss
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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