Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 Inflammasome Inhibitor for Potential Treatment of Multiple Sclerosis. [electronic resource]
Producer: 20180710Description: 2194-2201 p. digitalISSN:- 1948-7193
- Animals
- Benzamides -- pharmacology
- Carrier Proteins -- metabolism
- Cells, Cultured
- Encephalomyelitis, Autoimmune, Experimental -- drug therapy
- Inflammasomes -- drug effects
- Interleukin-1beta -- metabolism
- Lipopolysaccharides -- pharmacology
- Macrophages -- metabolism
- Mice, Inbred C57BL
- Multiple Sclerosis -- drug therapy
- NLR Family, Pyrin Domain-Containing 3 Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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