The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. [electronic resource]
Producer: 20190429ISSN:- 2050-084X
- Breast Neoplasms -- pathology
- Drug Resistance, Neoplasm -- drug effects
- Estrogen Receptor alpha -- chemistry
- Female
- Fulvestrant -- pharmacology
- Humans
- Indoles -- chemistry
- Ligands
- MCF-7 Cells
- Mutant Proteins -- metabolism
- Mutation -- genetics
- Piperazines -- pharmacology
- Protein Binding -- drug effects
- Protein Domains
- Protein Structure, Secondary
- Pyridines -- pharmacology
- Raloxifene Hydrochloride -- pharmacology
- Selective Estrogen Receptor Modulators -- chemistry
- Structure-Activity Relationship
- Tamoxifen -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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