New pyrazolo[3,4-d]pyrimidine SRC inhibitors induce apoptosis in mesothelioma cell lines through p27 nuclear stabilization. [electronic resource]
Producer: 20120504Description: 929-38 p. digitalISSN:- 1476-5594
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Blotting, Western
- Cell Cycle -- drug effects
- Cell Line
- Cell Line, Tumor
- Cell Nucleus -- metabolism
- Cell Survival -- drug effects
- Cyclin D1 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- genetics
- Dose-Response Relationship, Drug
- Enzyme Stability -- drug effects
- Flow Cytometry
- Humans
- Mesothelioma -- genetics
- Molecular Structure
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyrazoles -- chemistry
- Pyrimidines -- chemistry
- RNA Interference
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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