Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin. [electronic resource]
Producer: 20071121Description: 4818-31 p. digitalISSN:- 0022-2623
- Administration, Oral
- Amides -- chemical synthesis
- Animals
- Anisoles -- chemical synthesis
- Antihypertensive Agents -- chemical synthesis
- Biological Availability
- Blood Pressure -- drug effects
- Callithrix
- Caprylates -- chemical synthesis
- Crystallography, X-Ray
- Heart Rate -- drug effects
- Humans
- Kinetics
- Models, Molecular
- Molecular Mimicry
- Molecular Structure
- Peptides -- chemistry
- Protein Binding
- Renin -- antagonists & inhibitors
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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