Interindividual variability of CYP2C19-catalyzed drug metabolism due to differences in gene diplotypes and cytochrome P450 oxidoreductase content. [electronic resource]
Producer: 20170309Description: 375-87 p. digitalISSN:- 1473-1150
- Activation, Metabolic
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Clopidogrel
- Cytochrome P-450 CYP2C19 -- genetics
- Cytochrome P-450 Enzyme System -- metabolism
- Female
- Gene Expression Regulation, Enzymologic
- Gene Frequency
- Genotype
- Humans
- Hydroxylation
- Infant
- Infant, Newborn
- Kinetics
- Linear Models
- Liver -- enzymology
- Male
- Mephenytoin -- metabolism
- Microsomes, Liver -- enzymology
- Middle Aged
- Multivariate Analysis
- Oxidation-Reduction
- Pharmacogenomic Variants -- genetics
- Phenotype
- Substrate Specificity
- Ticlopidine -- analogs & derivatives
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
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