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Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. [electronic resource] by
- Zobel, Kerry
- Wang, Lan
- Varfolomeev, Eugene
- Franklin, Matthew C
- Elliott, Linda O
- Wallweber, Heidi J A
- Okawa, David C
- Flygare, John A
- Vucic, Domagoj
- Fairbrother, Wayne J
- Deshayes, Kurt
Producer: 20070313
In:
ACS chemical biology vol. 1
Availability: No items available.
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9.
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Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. [electronic resource] by
- Cohen, Frederick
- Alicke, Bruno
- Elliott, Linda O
- Flygare, John A
- Goncharov, Tatiana
- Keteltas, Stephen F
- Franklin, Matthew C
- Frankovitz, Stacy
- Stephan, Jean-Philippe
- Tsui, Vickie
- Vucic, Domagoj
- Wong, Harvey
- Fairbrother, Wayne J
Producer: 20090420
In:
Journal of medicinal chemistry vol. 52
Availability: No items available.
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10.
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Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). [electronic resource] by
- Franklin, Matthew C
- Kadkhodayan, Saloumeh
- Ackerly, Heidi
- Alexandru, Daniela
- Distefano, Mark D
- Elliott, Linda O
- Flygare, John A
- Mausisa, Grace
- Okawa, David C
- Ong, Danny
- Vucic, Domagoj
- Deshayes, Kurt
- Fairbrother, Wayne J
Producer: 20030812
In:
Biochemistry vol. 42
Availability: No items available.
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11.
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Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. [electronic resource] by
- Cohen, Frederick
- Koehler, Michael F T
- Bergeron, Philippe
- Elliott, Linda O
- Flygare, John A
- Franklin, Matthew C
- Gazzard, Lewis
- Keteltas, Stephen F
- Lau, Kevin
- Ly, Cuong Q
- Tsui, Vickie
- Fairbrother, Wayne J
Producer: 20100705
In:
Bioorganic & medicinal chemistry letters vol. 20
Availability: No items available.
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12.
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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. [electronic resource] by
- Pillow, Thomas H
- Sadowsky, Jack D
- Zhang, Donglu
- Yu, Shang-Fan
- Del Rosario, Geoffrey
- Xu, Keyang
- He, Jintang
- Bhakta, Sunil
- Ohri, Rachana
- Kozak, Katherine R
- Ha, Edward
- Junutula, Jagath R
- Flygare, John A
Publication details: Chemical science Jan 2017
In:
Chemical science vol. 8
Availability: No items available.
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13.
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Cyclodextrin Reduces Intravenous Toxicity of a Model Compound. [electronic resource] by
- Mantik, Priscilla
- Xie, Minli
- Wong, Harvey
- La, Hank
- Steigerwalt, Ronald W
- Devanaboyina, Uday
- Ganem, Geoffrey
- Shih, Danny
- Flygare, John A
- Fairbrother, Wayne J
- Chakravarty, Paroma
- Russell, David
- Fernandez, Gilberto E
- Narang, Ajit S
Producer: 20200717
In:
Journal of pharmaceutical sciences vol. 108
Availability: No items available.
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14.
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Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology. [electronic resource] by
- Erickson, Rebecca I
- Tarrant, Jacqueline
- Cain, Gary
- Lewin-Koh, Sock-Cheng
- Dybdal, Noel
- Wong, Harvey
- Blackwood, Elizabeth
- West, Kristina
- Steigerwalt, Ronald
- Mamounas, Michael
- Flygare, John A
- Amemiya, Kenjie
- Dambach, Donna
- Fairbrother, Wayne J
- Diaz, Dolores
Producer: 20130611
In:
Toxicological sciences : an official journal of the Society of Toxicology vol. 131
Availability: No items available.
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15.
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Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists. [electronic resource] by
- Ndubaku, Chudi
- Varfolomeev, Eugene
- Wang, Lan
- Zobel, Kerry
- Lau, Kevin
- Elliott, Linda O
- Maurer, Brigitte
- Fedorova, Anna V
- Dynek, Jasmin N
- Koehler, Michael
- Hymowitz, Sarah G
- Tsui, Vickie
- Deshayes, Kurt
- Fairbrother, Wayne J
- Flygare, John A
- Vucic, Domagoj
Producer: 20090924
In:
ACS chemical biology vol. 4
Availability: No items available.
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16.
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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. [electronic resource] by
- Varfolomeev, Eugene
- Blankenship, John W
- Wayson, Sarah M
- Fedorova, Anna V
- Kayagaki, Nobuhiko
- Garg, Parie
- Zobel, Kerry
- Dynek, Jasmin N
- Elliott, Linda O
- Wallweber, Heidi J A
- Flygare, John A
- Fairbrother, Wayne J
- Deshayes, Kurt
- Dixit, Vishva M
- Vucic, Domagoj
Producer: 20080225
In:
Cell vol. 131
Availability: No items available.
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17.
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Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist. [electronic resource] by
- Wong, Harvey
- Gould, Stephen E
- Budha, Nageshwar
- Darbonne, Walter C
- Kadel, Edward E
- La, Hank
- Alicke, Bruno
- Halladay, Jason S
- Erickson, Rebecca
- Portera, Chia
- Tolcher, Anthony W
- Infante, Jeffery R
- Mamounas, Michael
- Flygare, John A
- Hop, Cornelis E C A
- Fairbrother, Wayne J
Producer: 20140624
In:
Drug metabolism and disposition: the biological fate of chemicals vol. 41
Availability: No items available.
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18.
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Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis. [electronic resource] by
- Wong, Harvey
- Budha, Nageshwar R
- West, Kristina
- Blackwood, Elizabeth
- Ware, Joseph A
- Yu, Ron
- Darbonne, Walter C
- Gould, Stephen E
- Steigerwalt, Ronald
- Erickson, Rebecca
- Hop, Cornelis E A C
- LoRusso, Patricia
- Eckhardt, S Gail
- Wagner, Andrew
- Chan, Iris T
- Mamounas, Michael
- Flygare, John A
- Fairbrother, Wayne J
Producer: 20130327
In:
Toxicological sciences : an official journal of the Society of Toxicology vol. 130
Availability: No items available.
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19.
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Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. [electronic resource] by
- Sleebs, Brad E
- Czabotar, Peter E
- Fairbrother, Wayne J
- Fairlie, W Douglas
- Flygare, John A
- Huang, David C S
- Kersten, Wilhelmus J A
- Koehler, Michael F T
- Lessene, Guillaume
- Lowes, Kym
- Parisot, John P
- Smith, Brian J
- Smith, Morey L
- Souers, Andrew J
- Street, Ian P
- Yang, Hong
- Baell, Jonathan B
Producer: 20110617
In:
Journal of medicinal chemistry vol. 54
Availability: No items available.
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20.
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Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers. [electronic resource] by
- Gregson, Stephen J
- Masterson, Luke A
- Wei, Binqing
- Pillow, Thomas H
- Spencer, Susan D
- Kang, Gyoung-Dong
- Yu, Shang-Fan
- Raab, Helga
- Lau, Jeffrey
- Li, Guangmin
- Lewis Phillips, Gail D
- Gunzner-Toste, Janet
- Safina, Brian S
- Ohri, Rachana
- Darwish, Martine
- Kozak, Katherine R
- Dela Cruz-Chuh, Josefa
- Polson, Andrew
- Flygare, John A
- Howard, Philip W
Producer: 20171229
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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