TGF-beta-mediated activation of RhoA signalling is required for efficient (V12)HaRas and (V600E)BRAF transformation. [electronic resource]
Producer: 20090310Description: 983-93 p. digitalISSN:- 1476-5594
- Actins -- metabolism
- Animals
- Benzamides -- pharmacology
- Blotting, Western
- Cell Transformation, Neoplastic -- genetics
- Cells, Cultured
- Cytoskeleton
- Dioxoles -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Fibroblasts -- cytology
- Fluorescent Antibody Technique
- Genes, ras -- physiology
- Guanosine Triphosphate -- metabolism
- Humans
- Mice
- NIH 3T3 Cells
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins B-raf -- genetics
- Rats
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta -- antagonists & inhibitors
- Signal Transduction
- Smad3 Protein -- metabolism
- Smad4 Protein -- metabolism
- Transfection
- Transforming Growth Factor beta -- pharmacology
- rho-Associated Kinases -- metabolism
- rhoA GTP-Binding Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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