The marine fungal metabolite, AD0157, inhibits angiogenesis by targeting the Akt signaling pathway. [electronic resource]
Producer: 20140915Description: 279-99 p. digitalISSN:- 1660-3397
- Angiogenesis Inhibitors
- Animals
- Apoptosis -- drug effects
- Capillaries -- physiology
- Caspases -- metabolism
- Cell Line, Tumor
- Chromatin -- metabolism
- DNA Fragmentation -- drug effects
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Embryo, Nonmammalian -- drug effects
- Endothelial Cells -- drug effects
- Enzyme Activation -- drug effects
- Extracellular Matrix -- drug effects
- Humans
- MAP Kinase Signaling System -- drug effects
- Mice
- Oncogene Protein v-akt -- drug effects
- Phosphorylation
- Quinones -- pharmacology
- Signal Transduction -- drug effects
- Succinimides -- pharmacology
- Zebrafish -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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