Aesculetin (6,7-dihydroxycoumarin) exhibits potent and selective antitumor activity in human acute myeloid leukemia cells (THP-1) via induction of mitochondrial mediated apoptosis and cancer cell migration inhibition. [electronic resource]
Producer: 20190715Description: 1563-1569 p. digitalISSN:- 1107-0625
- Apoptosis -- drug effects
- Caspase 3 -- genetics
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Umbelliferones -- pharmacology
- bcl-2-Associated X Protein -- genetics
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Publication Type: Journal Article
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