Determination of the importance of the stereochemistry of psorospermin in topoisomerase II-induced alkylation of DNA and in vitro and in vivo biological activity. [electronic resource]
Producer: 20060130Description: 1729-39 p. digitalISSN:- 1535-7163
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Body Weight
- Cell Line
- Cell Line, Tumor
- DNA -- chemistry
- DNA Topoisomerases, Type II -- metabolism
- Deoxycytidine -- administration & dosage
- Drug Screening Assays, Antitumor
- Epoxy Compounds -- chemistry
- In Vitro Techniques
- Inhibitory Concentration 50
- Leukemia -- drug therapy
- Lymphoma -- drug therapy
- Mice
- Mice, Nude
- Models, Chemical
- Models, Molecular
- Pancreatic Neoplasms -- drug therapy
- Stereoisomerism
- Time Factors
- Xanthones -- administration & dosage
- Gemcitabine
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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