Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin α4β7 and Development of Colitis in Mice. [electronic resource]
Producer: 20191219Description: 1293-1309 p. digitalISSN:- 1528-0012
- Adaptive Immunity
- Alkyl and Aryl Transferases -- deficiency
- Animals
- Case-Control Studies
- Cells, Cultured
- Chemotaxis, Leukocyte
- Colitis -- enzymology
- Colon -- enzymology
- Cytokines -- metabolism
- Disease Models, Animal
- Homeodomain Proteins -- genetics
- Humans
- Immunity, Innate
- Inflammation Mediators -- metabolism
- Integrins -- metabolism
- Lymphocyte Activation
- Mice, Knockout
- Neuropeptides -- genetics
- Signal Transduction
- T-Lymphocytes -- enzymology
- cdc42 GTP-Binding Protein -- genetics
- rac1 GTP-Binding Protein -- genetics
- rho GTP-Binding Proteins -- deficiency
- rhoA GTP-Binding Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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