Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice. [electronic resource]
Producer: 20100810Description: 20818-26 p. digitalISSN:- 1083-351X
- Animals
- Blotting, Western
- Cell Nucleus -- pathology
- Conserved Sequence
- Crosses, Genetic
- Embryo, Mammalian
- Fibroblasts -- cytology
- Introns
- Lamin Type A -- biosynthesis
- Methylation
- Mice
- Mice, Knockout
- Microscopy, Fluorescence
- Mutagenesis, Site-Directed
- Nuclear Proteins -- genetics
- Phenotype
- Protein Modification, Translational
- Protein Precursors -- genetics
- Vertebrates
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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