Design of Ionizable Lipids To Overcome the Limiting Step of Endosomal Escape: Application in the Intracellular Delivery of mRNA, DNA, and siRNA. [electronic resource]
Producer: 20160913Description: 3046-62 p. digitalISSN:- 1520-4804
- Animals
- Chemistry Techniques, Synthetic
- Cryoelectron Microscopy -- methods
- DNA -- administration & dosage
- Drug Delivery Systems -- methods
- Endosomes -- chemistry
- Fatty Acids, Monounsaturated -- chemistry
- HeLa Cells
- Humans
- Hydrophobic and Hydrophilic Interactions
- Lipids -- administration & dosage
- Liposomes -- chemistry
- Microscopy, Electron, Transmission -- methods
- Muscle, Smooth, Vascular -- cytology
- Quaternary Ammonium Compounds -- chemistry
- RNA, Messenger -- administration & dosage
- RNA, Small Interfering -- administration & dosage
- Rats
- Structure-Activity Relationship
- Transfection -- methods
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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