Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives. [electronic resource]
Producer: 20130509Description: 329-43 p. digitalISSN:- 1768-3254
- 3',5'-Cyclic-GMP Phosphodiesterases
- Carbolines -- chemical synthesis
- Cell Proliferation
- Cyclic Nucleotide Phosphodiesterases, Type 5 -- chemistry
- Diketopiperazines -- chemical synthesis
- Drug Design
- Enzyme Assays
- Humans
- Hydantoins -- chemical synthesis
- Hydrogen Bonding
- Inhibitory Concentration 50
- Kinetics
- Molecular Docking Simulation
- Phosphodiesterase 5 Inhibitors -- chemical synthesis
- Phosphoric Diester Hydrolases -- chemistry
- Protein Structure, Secondary
- Recombinant Proteins -- antagonists & inhibitors
- Structure-Activity Relationship
- Tadalafil
- Thermodynamics
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Publication Type: Journal Article
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