Design and synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as PDE 4B inhibitors endowed with bronchodilator activity. [electronic resource]
Producer: 20200212Description: e1900002 p. digitalISSN:- 1521-4184
- Animals
- Bronchodilator Agents -- chemical synthesis
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- metabolism
- Dose-Response Relationship, Drug
- Drug Design
- Humans
- Male
- Molecular Docking Simulation
- Molecular Structure
- Muscle Contraction -- drug effects
- Muscle, Smooth -- drug effects
- Phosphodiesterase 4 Inhibitors -- chemical synthesis
- Pyrimidines -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Structure-Activity Relationship
- Trachea -- drug effects
- Triazoles -- chemical synthesis
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Publication Type: Journal Article
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