Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition. [electronic resource]
Producer: 20140415Description: 733-58 p. digitalISSN:- 1520-4804
- Animals
- Azetidines -- chemical synthesis
- CHO Cells
- Cell Membrane Permeability
- Cognition -- drug effects
- Cricetinae
- Cricetulus
- Cyclopropanes -- chemical synthesis
- Dogs
- Histamine H3 Antagonists -- chemical synthesis
- Humans
- Learning -- drug effects
- Madin Darby Canine Kidney Cells
- Male
- Mice
- Microsomes, Liver -- metabolism
- Models, Molecular
- Piperazines -- chemical synthesis
- Piperidines -- chemical synthesis
- Pyrrolidines -- chemical synthesis
- Rats
- Rats, Sprague-Dawley
- Receptors, Histamine H3 -- genetics
- Recognition, Psychology -- drug effects
- Spiro Compounds -- chemical synthesis
- Stereoisomerism
- Structure-Activity Relationship
No physical items for this record
Publication Type: Journal Article
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