Experimentally validated HERG pharmacophore models as cardiotoxicity prediction tools. [electronic resource]
Producer: 20150626Description: 2887-901 p. digitalISSN:- 1549-960X
- Binding Sites
- Cardiotonic Agents -- chemistry
- Drug Design
- Drug Evaluation, Preclinical
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels -- antagonists & inhibitors
- Gene Expression
- HEK293 Cells
- High-Throughput Screening Assays
- Humans
- Ligands
- Membrane Potentials -- drug effects
- Molecular Conformation
- Molecular Dynamics Simulation
- Patch-Clamp Techniques
- Potassium Channel Blockers -- chemistry
- Protein Binding
- Recombinant Proteins -- chemistry
- Small Molecule Libraries -- chemistry
- Structure-Activity Relationship
- User-Computer Interface
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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