Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt. [electronic resource]
Producer: 20090707Description: 14157-64 p. digitalISSN:- 0021-9258
- Acrylamide
- Colipases -- metabolism
- Humans
- Kinetics
- Lactones -- pharmacology
- Lipase -- antagonists & inhibitors
- Mutant Proteins -- chemistry
- Orlistat
- Protein Conformation
- Spectrometry, Fluorescence
- Structure-Activity Relationship
- Taurodeoxycholic Acid -- pharmacology
- Time Factors
- Tryptophan -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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