Long-term estradiol exposure is a direct mitogen for insulin/EGF-primed endometrial cells and drives PTEN loss-induced hyperplasic growth. [electronic resource]
Producer: 20131024Description: 277-87 p. digitalISSN:- 1525-2191
- Animals
- Biomarkers -- metabolism
- Blotting, Western
- Cell Proliferation -- drug effects
- Endometrial Hyperplasia -- chemically induced
- Endometrium -- drug effects
- Epidermal Growth Factor -- metabolism
- Epithelial Cells -- drug effects
- Estradiol -- adverse effects
- Estrogens -- adverse effects
- Female
- Fluorescent Antibody Technique
- Insulin -- metabolism
- Insulin-Like Growth Factor I -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mitogens -- adverse effects
- PTEN Phosphohydrolase -- deficiency
- Real-Time Polymerase Chain Reaction
- Reverse Transcriptase Polymerase Chain Reaction
- Spheroids, Cellular
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Publication Type: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
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