SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. [electronic resource]
Producer: 20141222Description: 5855-65 p. digitalISSN:- 1538-7445
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Cell Cycle Checkpoints
- Cell Proliferation -- drug effects
- Dogs
- Drug Stability
- HCT116 Cells
- Humans
- Indoles -- pharmacology
- Mice
- Protein Binding
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-mdm2 -- metabolism
- Rats
- Remission Induction
- Spiro Compounds -- pharmacology
- Tumor Suppressor Protein p53 -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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