A balancing act between net uptake of water during dihydrofolate binding and net release of water upon NADPH binding in R67 dihydrofolate reductase. [electronic resource]
Producer: 20080410Description: 4690-8 p. digitalISSN:- 0021-9258
- Binding Sites -- physiology
- Catalysis
- Drug Resistance, Bacterial -- drug effects
- Escherichia coli -- enzymology
- Escherichia coli Proteins
- Folic Acid -- analogs & derivatives
- Folic Acid Antagonists -- chemistry
- NADP -- chemistry
- Osmosis -- drug effects
- Oxidation-Reduction -- drug effects
- Protein Structure, Quaternary
- Sorbitol -- pharmacology
- Sweetening Agents -- pharmacology
- Tetrahydrofolate Dehydrogenase -- chemistry
- Trimethoprim -- chemistry
- Water -- chemistry
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
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