Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01. [electronic resource]
Producer: 20161006Description: 180-5 p. digitalISSN:- 1473-1150
- Alanine Transaminase -- metabolism
- Alleles
- Antineoplastic Agents -- adverse effects
- Breast Neoplasms -- drug therapy
- Case-Control Studies
- Chemical and Drug Induced Liver Injury -- etiology
- ErbB Receptors -- metabolism
- Female
- Genome-Wide Association Study
- HLA-DRB1 Chains -- genetics
- Humans
- Hyperbilirubinemia -- chemically induced
- INDEL Mutation
- Lapatinib
- Polymorphism, Single Nucleotide
- Quinazolines -- adverse effects
- Risk
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Publication Type: Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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