P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. [electronic resource]
Producer: 20151009Description: 3968-76 p. digitalISSN:- 1476-5594
- Animals
- Breast Neoplasms -- metabolism
- Cell Survival
- Feedback, Physiological
- Female
- Guanine Nucleotide Exchange Factors -- physiology
- Humans
- MAP Kinase Signaling System
- MCF-7 Cells
- Mice, Inbred NOD
- Mice, SCID
- Mutation
- Neoplasm Transplantation
- Phosphatidylinositol 3-Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptors, Growth Factor -- metabolism
- rac GTP-Binding Proteins -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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