Phase I dose escalation study of NMS-1286937, an orally available Polo-Like Kinase 1 inhibitor, in patients with advanced or metastatic solid tumors. [electronic resource]
Producer: 20181227Description: 85-95 p. digitalISSN:- 1573-0646
- Administration, Oral
- Aged
- Antineoplastic Agents -- administration & dosage
- Cell Cycle Proteins -- antagonists & inhibitors
- Dose-Response Relationship, Drug
- Female
- Humans
- Male
- Maximum Tolerated Dose
- Middle Aged
- Neoplasms -- drug therapy
- Neutropenia -- chemically induced
- Protein Kinase Inhibitors -- administration & dosage
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins -- antagonists & inhibitors
- Thrombocytopenia -- chemically induced
- Treatment Outcome
- Polo-Like Kinase 1
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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