A Novel Mitochondrial Inhibitor Blocks MAPK Pathway and Overcomes MAPK Inhibitor Resistance in Melanoma. [electronic resource]
Producer: 20200908Description: 6429-6442 p. digitalISSN:- 1557-3265
- AMP-Activated Protein Kinase Kinases
- Animals
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Heterografts
- Humans
- MAP Kinase Signaling System -- drug effects
- Melanoma -- drug therapy
- Mice
- Mitochondria -- drug effects
- Oxadiazoles -- therapeutic use
- Oxidative Phosphorylation -- drug effects
- Piperidines -- therapeutic use
- Positron-Emission Tomography
- Protein Kinase Inhibitors -- pharmacology
- Protein Kinases -- genetics
- Proto-Oncogene Proteins B-raf -- genetics
- TOR Serine-Threonine Kinases -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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