SD0006: a potent, selective and orally available inhibitor of p38 kinase. [electronic resource]
Producer: 20091229Description: 42-60 p. digitalISSN:- 1423-0313
- Administration, Oral
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Arthritis, Experimental -- drug therapy
- Bone Density -- drug effects
- Cell Line
- Endotoxemia -- drug therapy
- Female
- Humans
- Inflammation -- drug therapy
- Inflammation Mediators -- antagonists & inhibitors
- Lipopolysaccharides -- pharmacology
- Macaca fascicularis
- Male
- Mice
- Mice, Inbred DBA
- Models, Molecular
- Pain -- drug therapy
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- Rats
- Rats, Inbred Lew
- Rats, Sprague-Dawley
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
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