Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation. [electronic resource]
Producer: 20140102Description: 3248-61 p. digitalISSN:- 1538-7445
- Animals
- Biomarkers, Tumor -- genetics
- Breast Neoplasms -- enzymology
- Cell Growth Processes -- physiology
- Cell Transformation, Neoplastic -- genetics
- Class I Phosphatidylinositol 3-Kinases
- Epithelial Cells -- enzymology
- Female
- Gene Knock-In Techniques
- Heterografts
- Humans
- Immunocompromised Host
- MAP Kinase Signaling System
- Mice
- Mice, Nude
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphorylation
- Point Mutation
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- genetics
- Proto-Oncogene Proteins p21(ras)
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase
- Ribosomal Protein S6 Kinases, 70-kDa -- metabolism
- Ribosomal Protein S6 Kinases, 90-kDa -- metabolism
- ras Proteins -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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