A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. [electronic resource]
Producer: 20100622Description: 671-7 p. digitalISSN:- 1546-170X
- Activating Transcription Factors -- antagonists & inhibitors
- Animals
- Apoptosis -- genetics
- Benzenesulfonates -- pharmacology
- Brain Neoplasms -- genetics
- Cyclic AMP Response Element-Binding Protein -- genetics
- Gene Expression Profiling
- Glioma -- genetics
- Humans
- Mice
- Mice, Inbred C57BL
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Transplantation
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- Pyridines -- pharmacology
- RNA Interference
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- genetics
- Sorafenib
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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