Bovine papillomavirus E2 protein activates a complex growth-inhibitory program in p53-negative HT-3 cervical carcinoma cells that includes repression of cyclin A and cdc25A phosphatase genes and accumulation of hypophosphorylated retinoblastoma protein. [electronic resource]
Producer: 19990908Description: 413-22 p. digitalISSN:- 1044-9523
- Animals
- CDC2-CDC28 Kinases
- Carrier Proteins
- Cattle
- Cell Cycle Proteins -- metabolism
- Cell Division
- Cyclin A -- genetics
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases -- genetics
- Cyclins -- biosynthesis
- DNA-Binding Proteins -- genetics
- E2F Transcription Factors
- E2F1 Transcription Factor
- Enzyme Inhibitors
- Female
- Gene Expression Regulation
- Growth Inhibitors -- metabolism
- HeLa Cells
- Humans
- Phosphoprotein Phosphatases -- metabolism
- Phosphorylation
- Protein Serine-Threonine Kinases -- genetics
- Protein Tyrosine Phosphatases -- genetics
- Repressor Proteins -- genetics
- Retinoblastoma Protein -- biosynthesis
- Retinoblastoma-Binding Protein 1
- Transcription Factor DP1
- Transcription Factors -- biosynthesis
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53
- Uterine Cervical Neoplasms
- Viral Proteins -- genetics
- cdc25 Phosphatases
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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