Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. [electronic resource]
Producer: 20081105Description: 114-23 p. digitalISSN:- 0165-5728
- 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer -- pharmacology
- Analgesics, Non-Narcotic -- pharmacology
- Analysis of Variance
- Animals
- Calcium -- metabolism
- Chemokine CXCL12 -- pharmacology
- Chemotaxis -- drug effects
- Dose-Response Relationship, Drug
- Dynorphins -- metabolism
- Flow Cytometry -- methods
- Gene Expression -- drug effects
- Gene Expression Regulation -- drug effects
- HIV-1 -- physiology
- Humans
- Neutrophils -- drug effects
- Periaqueductal Gray -- drug effects
- Protein Transport -- drug effects
- Rats
- Receptors, CXCR4 -- genetics
- Receptors, Opioid, kappa -- genetics
- Time Factors
- Transfection -- methods
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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