Patient-derived iPSCs show premature neural differentiation and neuron type-specific phenotypes relevant to neurodevelopment. [electronic resource]
Producer: 20190812Description: 1687-1698 p. digitalISSN:- 1476-5578
- Cell Culture Techniques
- Ectodermal Dysplasia -- metabolism
- Facies
- Failure to Thrive -- metabolism
- Heart Defects, Congenital -- metabolism
- Humans
- Induced Pluripotent Stem Cells -- drug effects
- MAP Kinase Signaling System -- drug effects
- Mutation
- Neurogenesis -- drug effects
- Neurons -- drug effects
- Phenotype
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins B-raf -- genetics
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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