Phase I study of PF‐04895162, a Kv7 channel opener, reveals unexpected hepatotoxicity in healthy subjects, but not rats or monkeys: clinical evidence of disrupted bile acid homeostasis. [electronic resource]
Producer: 20190415Description: e00467 p. digitalISSN:- 2052-1707
- Adult
- Animals
- Bile Acids and Salts -- metabolism
- Biological Transport -- drug effects
- Chemical and Drug Induced Liver Injury -- etiology
- Double-Blind Method
- Hepatocytes -- drug effects
- Homeostasis
- Humans
- Macaca fascicularis
- Male
- Mitochondria, Liver -- drug effects
- Rats
- Risk Factors
- Species Specificity
- Transaminases -- metabolism
- Young Adult
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Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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