Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses. [electronic resource]
Producer: 20040217Description: 291-300 p. digitalISSN:- 0006-4971
- Apoptosis -- genetics
- Ataxia Telangiectasia Mutated Proteins
- Cell Cycle Proteins
- Cell Survival -- genetics
- DNA Damage
- DNA-Binding Proteins
- Gene Expression Profiling
- Genes, p53
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- classification
- Mutation
- Oligonucleotide Array Sequence Analysis
- Protein Serine-Threonine Kinases -- genetics
- Transcriptional Activation -- radiation effects
- Tumor Suppressor Proteins
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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