Nucleotide sequencing of psoriatic arthritis tissue before and during methotrexate administration reveals a complex inflammatory T cell infiltrate with very few clones exhibiting features that suggest they drive the inflammatory process by recognizing autoantigens. [electronic resource]
Producer: 20040507Description: 1935-44 p. digitalISSN:- 0022-1767
- Amino Acid Sequence
- Arthritis, Psoriatic -- blood
- Autoantigens -- immunology
- Base Sequence
- CD4-Positive T-Lymphocytes -- drug effects
- CD8-Positive T-Lymphocytes -- drug effects
- Cell Lineage -- genetics
- Cell Movement -- drug effects
- Clone Cells
- Complementarity Determining Regions -- analysis
- Humans
- Lymphocyte Activation -- genetics
- Methotrexate -- administration & dosage
- Molecular Sequence Data
- Receptors, Antigen, T-Cell, alpha-beta -- genetics
- Sequence Analysis, DNA -- methods
- Synovial Fluid -- cytology
- T-Lymphocyte Subsets -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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