Ibrutinib downregulates a subset of miRNA leading to upregulation of tumor suppressors and inhibition of cell proliferation in chronic lymphocytic leukemia. [electronic resource]
Producer: 20170901Description: 340-349 p. digitalISSN:- 1476-5551
- Adenine -- analogs & derivatives
- Adult
- Aged
- Antigens, CD19 -- genetics
- B-Lymphocytes -- metabolism
- Biomarkers -- metabolism
- Cell Proliferation -- drug effects
- Cluster Analysis
- Down-Regulation
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Leukemic -- drug effects
- Gene Knockdown Techniques
- Genes, Tumor Suppressor
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell -- diagnosis
- Lymph Nodes -- metabolism
- Male
- MicroRNAs -- genetics
- Middle Aged
- Phenotype
- Piperidines
- Protein Kinase Inhibitors -- pharmacology
- Pyrazoles -- pharmacology
- Pyrimidines -- pharmacology
- RNA Interference
- RNA, Messenger -- genetics
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Publication Type: Journal Article
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