MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy. [electronic resource]
Producer: 20130206Description: 913-29 p. digitalISSN:- 1528-3658
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cyclin-Dependent Kinase Inhibitor p21 -- genetics
- DNA Modification Methylases -- antagonists & inhibitors
- DNA Repair Enzymes -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Inhibitors -- pharmacology
- Estrogen Antagonists -- pharmacology
- Estrogen Receptor alpha -- metabolism
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- Guanine -- analogs & derivatives
- Humans
- Immunohistochemistry
- Mice
- Mice, Nude
- Phosphorylation -- drug effects
- Phosphoserine -- metabolism
- Promoter Regions, Genetic -- genetics
- Protein Binding -- drug effects
- Tamoxifen -- therapeutic use
- Transcription, Genetic -- drug effects
- Tumor Suppressor Protein p53 -- metabolism
- Tumor Suppressor Proteins -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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