Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion. [electronic resource]
Producer: 20200727Description: 1533 p. digitalISSN:- 2041-1723
- Animals
- Cell Communication -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation
- Gene Knockdown Techniques
- Glucose -- metabolism
- Glucose Transporter Type 1 -- antagonists & inhibitors
- Humans
- Lung Neoplasms -- drug therapy
- Mice
- Neoplasm Invasiveness -- pathology
- Oxidative Phosphorylation
- Pyruvate Dehydrogenase (Lipoamide) -- antagonists & inhibitors
- RNA, Small Interfering -- metabolism
- Spheroids, Cellular
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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