Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists. [electronic resource]
Producer: 20060802Description: 3444-8 p. digitalISSN:- 0960-894X
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Computer Simulation
- Crystallography, X-Ray
- Drug Design
- Drug Evaluation, Preclinical
- Enzyme Inhibitors -- chemical synthesis
- Humans
- Models, Molecular
- Molecular Structure
- Receptor, trkA -- antagonists & inhibitors
- Stereoisomerism
- Structure-Activity Relationship
- Thiazoles -- chemical synthesis
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Publication Type: Journal Article
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