Improved safety margin for embryotoxicity in rats for the new endoperoxide artefenomel (OZ439) as compared to artesunate. [electronic resource]
Producer: 20190322Description: 553-578 p. digitalISSN:- 2472-1727
- Adamantane -- analogs & derivatives
- Animals
- Antimalarials -- toxicity
- Artemisinins -- toxicity
- Artesunate -- toxicity
- Benzoxazines -- toxicity
- Dose-Response Relationship, Drug
- Embryo, Mammalian -- drug effects
- Female
- Fetal Development -- drug effects
- Gestational Age
- Heme -- biosynthesis
- Organ Culture Techniques
- Organogenesis -- drug effects
- Peroxides -- pharmacokinetics
- Phthalimides -- toxicity
- Rats
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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