N-acetylcysteine and 15 deoxy-{delta}12,14-prostaglandin J2 exert a protective effect against autoimmune thyroid destruction in vivo but not against interleukin-1{alpha}/interferon {gamma}-induced inhibitory effects in thyrocytes in vitro. [electronic resource]
Producer: 20101206Description: 219-28 p. digitalISSN:- 1525-2191
- Acetylcysteine -- pharmacology
- Animals
- Cells, Cultured
- Female
- Humans
- Immunologic Factors -- pharmacology
- Interferon-gamma -- pharmacology
- Interleukin-1alpha -- pharmacology
- Mice
- Mice, Inbred NOD
- Peroxiredoxins -- metabolism
- Prostaglandin D2 -- analogs & derivatives
- Rats
- Reactive Oxygen Species -- metabolism
- Recombinant Proteins
- Thyroid Gland -- cytology
- Thyroiditis, Autoimmune -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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