Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. [electronic resource]
Producer: 20060417Description: 1679-85 p. digitalISSN:- 0960-894X
- Adenosine Triphosphate -- metabolism
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Calcium-Calmodulin-Dependent Protein Kinases -- antagonists & inhibitors
- Cell Proliferation -- drug effects
- Enzyme Inhibitors -- chemical synthesis
- Ethylenes -- chemical synthesis
- Glycogen Synthase Kinase 3
- Humans
- Neoplasms -- drug therapy
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Structure-Activity Relationship
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Publication Type: Evaluation Study; Journal Article
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